Linked Life Data

6977371

Source:http://linkedlifedata.com/resource/pubmed/id/6977371

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-5-21
pubmed:abstractText
Four patients with chronic lymphocytic leukaemia were treated with splenic irradiation, 100 rads per week for 10 weeks. No patient had received prior therapy of any kind. All patients showed an excellent clinical response in terms of decrease in lymphocyte count in blood and bone marrow and decrease in lymph node and spleen size. B and T cell populations returned to normal in all patients as did the ratio of TG to TM cells. Two patients showed an increase in IgM levels, but the overall pattern of immunoglobulins showed no consistent change following treatment. No toxicity was incurred during treatment. We conclude that splenic irradiation is a safe and effective treatment of previously untreated patients with CLL and is associated with a return to normal of lymphocyte sub-populations. The role of the abnormal T cell population in the pathogenesis of the hypoimmunoglobulinaemia remains unclear.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Lymphocyte sub-populations following splenic irradiation in patients with chronic lymphocytic leukaemia.
pubmed:publicationType
Journal Article