|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1982-4-20
|
|
pubmed:abstractText |
Infective influenza virus primes mice and increases at least ten-fold the level of splenic cytotoxic T-memory and precursor cells in comparison with normal mice. Intranasal virus infection or intraperitoneal injection of infective virus results in frequencies of 1-2 x 10(-4) cytotoxic T-cell precursors in spleen as determined by limiting dilution assays. With both types of immunization, T-helper cells amplifying the generation of T-killer cells are limiting, and optimal clone frequencies depend on addition of excess T-helper cells. We find that at least part of the T-helper cells amplifying the generation of cytotoxic T cells are cross reactive for the type A influenza viruses and therefore have a similar virus specificity to type A influenza-specific cytotoxic T cells (tc). Help for T-killer cells can be replaced by supernatants derived from Concanavalin A-stimulated rat spleen cells, but presence of antigen is still required to stimulate the Tc precursor or memory cells before they respond to antigen non-specific T cell-growth factor(s) present in the stimulated rat spleen cell medium.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-1083894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-145543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-156218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-194164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-227982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-233899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-233901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-300355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-303150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-303568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-306072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-308188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-330390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-6965304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-6968871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6976928-91527
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
45
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
79-84
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6976928-Animals,
pubmed-meshheading:6976928-Cross Reactions,
pubmed-meshheading:6976928-Cytotoxicity, Immunologic,
pubmed-meshheading:6976928-Female,
pubmed-meshheading:6976928-Immunologic Memory,
pubmed-meshheading:6976928-Killer Cells, Natural,
pubmed-meshheading:6976928-Leukocyte Count,
pubmed-meshheading:6976928-Mice,
pubmed-meshheading:6976928-Mice, Inbred BALB C,
pubmed-meshheading:6976928-Orthomyxoviridae Infections,
pubmed-meshheading:6976928-Spleen,
pubmed-meshheading:6976928-T-Lymphocytes
|
|
pubmed:year |
1982
|
|
pubmed:articleTitle |
Cytotoxic T-memory cells in virus infection and the specificity of helper T cells.
|
|
pubmed:publicationType |
Journal Article
|
