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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003320,
umls-concept:C0024518,
umls-concept:C0028778,
umls-concept:C0031437,
umls-concept:C0039194,
umls-concept:C0237881,
umls-concept:C0441655,
umls-concept:C0456387,
umls-concept:C0542341,
umls-concept:C0750502
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pubmed:issue |
11
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pubmed:dateCreated |
1982-2-12
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pubmed:abstractText |
The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of anti-Lyt2 without complement to in vitro cultures blocked the generation of allogeneic MHC-induced help and lymphokine production and cytotoxic effects when the response was directed against allogeneic class 1 MHC antigens (K and D gene products of the mouse H-2 complex) but had no effect when these responses were specific for class 2 MHC antigens (I region gene products). Anti-Lyt2 failed to block the response of help induced to allogeneic mixed lymphocyte-stimulating determinants or the production of lymphokines by T cells specific for class 1 MHC antigens when concanavalin A lectin was used to induce activity. These and earlier results indicate that the ability of anti-Lyt2 antisera to block function is correlated with T cell specificity for class 1 MHC antigens not with the functional activity of the cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-100571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-1078839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-1085419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-113478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-129707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-148487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-161527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-302190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-310839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-315987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-4109111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-4126264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-4404878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-47901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-4936290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-53265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-58463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-5849237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6164727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6445920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6447723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6452474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6787609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6788878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6967414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6967947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6968693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6972039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-6972304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-7000676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-833548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-88050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975943-96182
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7101-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6975943-Animals,
pubmed-meshheading:6975943-Antibodies, Monoclonal,
pubmed-meshheading:6975943-Antigens, Ly,
pubmed-meshheading:6975943-Cytotoxicity, Immunologic,
pubmed-meshheading:6975943-Major Histocompatibility Complex,
pubmed-meshheading:6975943-Mice,
pubmed-meshheading:6975943-Mice, Inbred Strains,
pubmed-meshheading:6975943-Phenotype,
pubmed-meshheading:6975943-Spleen,
pubmed-meshheading:6975943-T-Lymphocytes
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pubmed:year |
1981
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pubmed:articleTitle |
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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