Linked Life Data

6975356

Source:http://linkedlifedata.com/resource/pubmed/id/6975356

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-1-20
pubmed:abstractText
Distributions of peripheral blood lymphocyte subpopulations and T-cell subsets were studied in 38 patients with myasthenia gravis (MG) and 23 healthy controls. T cells were detected by rosette formation with sheep red blood cells and B cells with erythrocyte-antibody-complement (EAC) complexes. T mu cells were identified by rosette formation of T cells with Ox RBC-IgM complexes, and T gamma cells with Ox RBC-IgG complexes. The means of total lymphocyte count and active T cell percentage were marginally significantly lower in MG patients than in normal controls (0.05 less than P less than 0.1). The mean percentage of T mu cells was higher in MG patients than in controls (50.2 +/- 11.8% vs. 38.5 +/- 15.3%, P less than 0.01), whereas that of T gamma cells in the former was lower than that in the latter (20.4 +/- 7.1% vs. 27.6 +/- 6.2%, P less than 0.001). Thus, the loss of regulatory suppressor T cells and the increase of helper T cells in the patients are in favour of regarding MG as an autoimmune disease. The fact that the percentage of T gamma cells was significantly decreased in MG patients after autologus serum incubation, and that no such a phenomenon was seen in normal controls, may suggest a possible role of serum factors in the pathogenesis of MG.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Imbalances in T-cell subpopulations in myasthenia gravis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't