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rdf:type |
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lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0024299,
umls-concept:C0039194,
umls-concept:C0080202,
umls-concept:C0439851,
umls-concept:C0597032,
umls-concept:C0936012,
umls-concept:C1552596,
umls-concept:C1554184,
umls-concept:C1947931,
umls-concept:C2362651,
umls-concept:C2745888
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pubmed:issue |
5
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pubmed:dateCreated |
1982-1-20
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pubmed:abstractText |
In the course of analyzing human lymphoma tissue with conventional surface marker techniques and with monoclonal antibodies directed against T cell subsets, five tumors were encountered with dual B and T cell determinants. All bore on their surface membrane IgM of kappa light chain type, complement receptors, and the Ia-like antigen. In each of the five cases, the neoplastic lymphocytes reacted with a monoclonal antibody that detects the sheep erythrocyte receptor (OKT11); all but one reacted with a monoclonal antibody for peripheral T cells (OKT3); and all but one reacted with a monoclonal antibody specific for either the inducer-helper (OKT4) or the cytotoxic-suppressor (OKT8) T cell subsets. In addition, lymphocytes from two of the five cases formed spontaneous rosettes with sheep erythrocytes (E-rosettes). These tumors with dual B and T surface characteristics were confined to human malignant lymphomas that originate from B lymphocytes of the follicle center.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-1082857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-14286814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-185059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-291439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-326316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-407477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-4134370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-4546025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-4589574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-5066536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6158547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6450262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6766752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6965347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6966400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6967511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6968995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6969365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-6993560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-788814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-803233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6975352-94505
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1709-14
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6975352-Animals,
pubmed-meshheading:6975352-Antibodies, Monoclonal,
pubmed-meshheading:6975352-B-Lymphocytes,
pubmed-meshheading:6975352-Cell Transformation, Neoplastic,
pubmed-meshheading:6975352-Goats,
pubmed-meshheading:6975352-Humans,
pubmed-meshheading:6975352-Leukemia,
pubmed-meshheading:6975352-Leukemia, Lymphoid,
pubmed-meshheading:6975352-Leukemia, Myeloid,
pubmed-meshheading:6975352-Lymphoma,
pubmed-meshheading:6975352-Lymphoma, Non-Hodgkin,
pubmed-meshheading:6975352-Mice,
pubmed-meshheading:6975352-Mice, Inbred Strains,
pubmed-meshheading:6975352-Rabbits,
pubmed-meshheading:6975352-Receptors, Antigen, B-Cell,
pubmed-meshheading:6975352-Rosette Formation,
pubmed-meshheading:6975352-Sheep,
pubmed-meshheading:6975352-T-Lymphocytes
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pubmed:year |
1981
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pubmed:articleTitle |
Malignant lymphoma with dual B and T cell markers. Analysis of the neoplastic cells with monoclonal antibodies directed against T cell subsets.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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