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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1982-1-28
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pubmed:abstractText |
IL 2 production was studied in autoimmune mice to assess the role of this lymphokine in the pathogenesis of murine lupus. Spleen and lymph node cells from autoimmune-susceptible mice show an age-dependent loss in the ability to produce functional IL 2. This defect correlates with disease expression and is most severe in MLR/Mp-Ipr/Ipr mice. MLR/Mp-Ipr/Ipr thymocytes gradually lose responsiveness to IL 2 with age. These results suggest that the immunoregulatory abnormalities of autoimmune mice may be due in part to IL 2 deficiency.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2483-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6975325-Aging,
pubmed-meshheading:6975325-Animals,
pubmed-meshheading:6975325-Autoimmune Diseases,
pubmed-meshheading:6975325-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6975325-Interleukin-2,
pubmed-meshheading:6975325-Lymphoid Tissue,
pubmed-meshheading:6975325-Lymphokines,
pubmed-meshheading:6975325-Mice,
pubmed-meshheading:6975325-Mice, Inbred C57BL,
pubmed-meshheading:6975325-Mice, Inbred CBA,
pubmed-meshheading:6975325-Mice, Inbred DBA,
pubmed-meshheading:6975325-Mice, Inbred NZB
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pubmed:year |
1981
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pubmed:articleTitle |
Interleukin 2 deficiency is a common feature of autoimmune mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|