6974624

Source:http://linkedlifedata.com/resource/pubmed/id/6974624

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003873, umls-concept:C0018956, umls-concept:C0030705, umls-concept:C0039194, umls-concept:C0086418, umls-concept:C0229664, umls-concept:C0679215
pubmed:issue	3
pubmed:dateCreated	1981-12-21
pubmed:abstractText	We studied T cell subpopulations and their immunoregulatory circuits in the peripheral blood of 16 patients with rheumatoid arthritis (RA) who were receiving no medications that might interfere with the results. We found normal T cells with receptors for the Fc portion of IgG or IgM as well as autologous rosette-forming T cells (Tar cells), a subpopulation of T cells we have found to have the properties of human post-thymic precursors. We also found that peripheral blood cells of RA patients have normal concanavalin A-induced or spontaneously-expanded suppressor cell functions. Also normal were the characteristic functions of the Tar cells; feedback inhibition and the generation of suppression. The normal state of these T cell subpopulations and immunoregulatory circuits in the peripheral blood of patients with RA contrasts with their various abnormalities in other connective tissue diseases. This may either mean that the immunoregulatory aberration in RA involves primarily B cells, or, if it involves T cells, that it does so primarily in the synovial membrane.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-13596783, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-161065, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-304784, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-311785, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-316754, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-36903, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-376727, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-6444819, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-6447710, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-6998486, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974624-7444230
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0057202
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0009-9104
pubmed:author	pubmed-author:Alarcón-SegoviaDD, pubmed-author:PalaciosRR, pubmed-author:Ruíz-ArguellesAA
pubmed:issnType	Print
pubmed:volume	43
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	473-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:6974624-Arthritis, Rheumatoid, pubmed-meshheading:6974624-Concanavalin A, pubmed-meshheading:6974624-Feedback, pubmed-meshheading:6974624-Humans, pubmed-meshheading:6974624-Rosette Formation, pubmed-meshheading:6974624-T-Lymphocytes
pubmed:year	1981
pubmed:articleTitle	Human post-thymic precursor cells in health and disease. IX. Immunoregulatory T cell circuits in peripheral blood of patients with rheumatoid arthritis.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't