Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-11-22
pubmed:abstractText
We tested the proliferative responses of splenocytes from a panel of inbred mouse strains to AVIS, a B cell mitogen from Actinomyces viscosus bacteria. The SM/J strain was found to exhibit severalfold higher responsiveness than any of the other strains. SM/J splenocytes were also hyperresponsive to the B cell mitogens lipopolysaccharide, dextran sulfate, and purified protein derivative of tuberculin, but responsiveness to the T cell mitogen phytohemagglutinin was normal. (B6 X SM)F1 and F1 x B6 backcross mice were tested for AVIS and lipopolysaccharide responsiveness, and it was determined that hyperresponsiveness was under polygenic, autosomal, non-H-2-linked gene control. Genetic control of response to B mitogens in SM/J mice appears to be expressed solely through the B lymphocyte because removal of T lymphocytes or macrophages did not reduce the magnitude of responsiveness in vitro. SM/J mice may provide a useful model for testing questions regarding B cell triggering, differentiation, and function, and to examine the genes involved with B cell proliferation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-1083559, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-1103381, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-114305, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-163691, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-197167, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-307586, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-311808, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-312863, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-323400, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-325169, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-363941, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-363946, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4138849, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4288309, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4539345, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4563347, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4568761, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4587740, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4602658, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4604327, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4607609, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-4609774, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-66295, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-6967454, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-6997099, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-7358096, http://linkedlifedata.com/resource/pubmed/commentcorrection/6974217-805203
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
726-36
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Immune responsiveness of SM/J mice. Cellular characteristics and genetic analysis of hyperresponsiveness to B cell mitogens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.