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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1978-11-29
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pubmed:abstractText |
The pharmacokinetics of cefaclor and cephalexin were characterized in patients with creatinine clearances ranging from 0 to 147 ml/min. Each of 24 fasted subjects received a single 500-mg oral dose of cefaclor, and 13 of these subjects later received 500 mg of cephalexin. Serum and urine levels of the antibiotics were measured by bioassay. The serum half-lives were highly correlated with corrected creatinine clearance (cefaclor r = 0.92, cephalexin r = 0.94). Linear regression estimates of the half-life of cefaclor were 2.3 h in the anephric patient and 40 min in the patient with a corrected creatinine clearance of 100 ml/min. For cephalexin, corresponding half-lives were 15.4 h and 58 min. We present a dosage nomogram for calculating the appropriate adjustments to the loading dose based on patient weight and maintenence dose based on corrected creatinine clearance.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
172-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:697345-Adult,
pubmed-meshheading:697345-Aged,
pubmed-meshheading:697345-Cephalexin,
pubmed-meshheading:697345-Cephalosporins,
pubmed-meshheading:697345-Drug Administration Schedule,
pubmed-meshheading:697345-Half-Life,
pubmed-meshheading:697345-Humans,
pubmed-meshheading:697345-Kidney Diseases,
pubmed-meshheading:697345-Kinetics,
pubmed-meshheading:697345-Male,
pubmed-meshheading:697345-Middle Aged
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pubmed:year |
1978
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pubmed:articleTitle |
Pharmacokinetics of cefaclor and cephalexin: dosage nomograms for impaired renal function.
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pubmed:publicationType |
Journal Article
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