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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1981-8-10
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pubmed:abstractText |
The lymphokine Interleukin 2(IL2) restores T cell responses in a number of in vitro systems where immunogenicity has been compromised. UV irradiation of the stimulating allogeneic cells in a mixed leukocyte culture eliminates the production of cytotoxic T lymphocytes and greatly reduces the DNA synthesis response. IL2 restores both parameters. UV-irradiated stimulators are also unable to induce the normal production of IL2 which is observed in a mixed leukocyte culture. The cytotoxic activity of allogeneically stimulated thymocytes is almost completely lost within 24 hours after removal of IL2 at 5 days, indicating that the lymphokine is continuously required to maintain CTL. Thymocytes in 4-day cultures do not adsorb IL2 unless they are simultaneously activated with a mitogen. Finally, IL2 does not adequately restore a secondary response to the purified protein derivative of tuberculin (PPD) in adherent-cell-depleted cultures, indicating that macrophages, in addition to being required for IL2 production, have other functions. These probably include the presentation of soluble antigens to responding cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0091-7419
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6972471-Animals,
pubmed-meshheading:6972471-Cytotoxicity, Immunologic,
pubmed-meshheading:6972471-Immunity, Cellular,
pubmed-meshheading:6972471-Interleukin-2,
pubmed-meshheading:6972471-Lymphocyte Activation,
pubmed-meshheading:6972471-Lymphokines,
pubmed-meshheading:6972471-Macrophages,
pubmed-meshheading:6972471-Mice,
pubmed-meshheading:6972471-Mice, Inbred Strains,
pubmed-meshheading:6972471-T-Lymphocytes,
pubmed-meshheading:6972471-Ultraviolet Rays
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pubmed:year |
1980
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pubmed:articleTitle |
Interleukin 2 in cell-mediated immune responses.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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