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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1981-7-9
|
| pubmed:abstractText |
Frog (Rana temporaria) fundic mucosae in vitro were pretreated with the histamine H2 receptor antagonist Metiamide (10(-3)M, nutrient side) until net H+ secretion had ceased and a steady rate of HCO3- transport (luminal alkalinization) was titrated. Removal of Cl- with SO4(2) or isethionate replacement from solutions bathing both sides of the mucosa abolished luminal alkalinization. Readdition of Cl- to the luminal side only reestablished full rates of HCO3- transport. Nutrient (serosal) side Cl- had no effect in this aspect. The results support the previous suggestion that the gastric HCO3- transport process is located at the luminal membrane of the surface epithelial cells and indicate that it occurs by (electroneutral) HCO3-/Cl- exchange.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-9734
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
303-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1980
|
| pubmed:articleTitle |
Cl- dependence of HCO3- transport in frog gastric mucosa.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|