Linked Life Data

6971823

Source:http://linkedlifedata.com/resource/pubmed/id/6971823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-7-9
pubmed:abstractText
The quantitative distribution of cell surface alterations of heated P388 ascites tumour cells was determined by scanning electron microscopy. Cells harvested from host animals maintained on a standard rodent chow diet or one high in saturated fatty acids responded differently, to identical hyperthermic treatment in vitro, to cells obtained from animals on a highly unsaturated diet. The morphological response of cells from chow fed animals was modified by addition to the incubation medium, of procaine, a membrane-active drug. The pattern of response observed after these cells were heated in the presence of procaine resembled that seen following heat treatment of ascites cells obtained from animals fed diet high in unsaturated fatty acids. These data are consistent with the hypothesis that a cell's response to hyperthermic insult is related to its membrane fluidity at the time of treatment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0020-7616
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-106
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Hyperthermia and surface morphology of P388 ascites tumour cells: effects of membrane modifications.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.