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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1981-6-23
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pubmed:abstractText |
The cellular basis of the immune unresponsiveness induced by lipopolysaccharide (LPS) was analyzed at the B and T cell level. The immunosuppressive effect of LPS is not related to altered B cell competence. Inhibition of antibody responses was observed only for thymus-dependent (TD) and not for thymus-independent antigens. In the presence of T cell-replacing factor (TRF), LPS-sensitized B lymphocytes respond to TD antigenic stimulation and differentiate into antibody-forming cells. Evidence is presented for a decreased helper activity of LPS-sensitized T lymphocytes and for a defective production of TRF in concanavalin A-stimulated spleen cells from LPS-treated mice. The implication of a cell compartment other than T is discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6971225-Animals,
pubmed-meshheading:6971225-Antibody-Producing Cells,
pubmed-meshheading:6971225-B-Lymphocytes,
pubmed-meshheading:6971225-Cell Differentiation,
pubmed-meshheading:6971225-Female,
pubmed-meshheading:6971225-Immune Tolerance,
pubmed-meshheading:6971225-Lipopolysaccharides,
pubmed-meshheading:6971225-Mice,
pubmed-meshheading:6971225-Mice, Inbred C57BL,
pubmed-meshheading:6971225-Mice, Inbred DBA,
pubmed-meshheading:6971225-Spleen,
pubmed-meshheading:6971225-Thymus Gland
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pubmed:year |
1981
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pubmed:articleTitle |
Immune unresponsiveness of spleen cells from lipopolysaccharide-treated mice to particulate thymus-dependent antigen. I. Evidence for differentiation signal defect.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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