Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1981-5-13
|
| pubmed:abstractText |
A panel of reagents (OKT1, 3, 4, 6, 8, and 11) detects differentiation antigens expressed exclusively on HuTLA+ T lymphoid cells but absent on bone marrow precursors, such as terminal deoxynucleotidyl transferase- (TdT) positive cells, immature myeloblasts, and other myeloid/erythroid cell types. In the bone marrow no transitional forms could be detected between TdT+ and T cells. The BM T cells showed mostly the suppressor/cytotoxic phenotype (OKT8+) with only a few T cells of inducer type (OKT4+). Thymocyte heterogeneity was also analyzed directly in tissue sections and in double labeling assays in combination with TdT staining, a marker for cortical thymocytes. Many large thymic blasts (in fetal and infant thymus) showed reactivity with OKT11--a pan-T reagent, but had only weak or negligible activity with the other antibodies. Cortical thymocytes reacted strongly with OKT11, 6, 4, and 8, whereas medullary cells reacted with OKT11, 3, 4 (majority) and 8 (minority). Thus, the reactivity with these antibodies is generated in the thymus at various stages of differentiation. In contrast, OKT10 (an anti-"precursor cell" reagent) reacted not only with thymocytes but also with TdT+ BM precursors, myeloblasts, and BM B lymphocytes although it was unreactive with mature peripheral lymphoid and maturing myelo/erythroid cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
126
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1608-13
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6970781-Adolescent,
pubmed-meshheading:6970781-Adult,
pubmed-meshheading:6970781-Animals,
pubmed-meshheading:6970781-Antibodies,
pubmed-meshheading:6970781-Antilymphocyte Serum,
pubmed-meshheading:6970781-Bone Marrow,
pubmed-meshheading:6970781-Child,
pubmed-meshheading:6970781-Child, Preschool,
pubmed-meshheading:6970781-Clone Cells,
pubmed-meshheading:6970781-Female,
pubmed-meshheading:6970781-Fetus,
pubmed-meshheading:6970781-Horses,
pubmed-meshheading:6970781-Humans,
pubmed-meshheading:6970781-Leukemia, Lymphoid,
pubmed-meshheading:6970781-Mice,
pubmed-meshheading:6970781-Pregnancy,
pubmed-meshheading:6970781-Rabbits,
pubmed-meshheading:6970781-T-Lymphocytes,
pubmed-meshheading:6970781-Thymus Gland
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Distribution of t lymphocyte subsets in the human bone marrow and thymus: an analysis with monoclonal antibodies.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|