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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-5-28
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pubmed:abstractText |
T lymphocyte subpopulations (T gamma and Tmu) were studied in a group of 36 adult patients with immunodeficiency. Proportions and numbers of Ia(+) T cells were also studied in comparison to 46 normal adult controls. Values for per cent and total numbers of T gamma and Tmu cells indicated no uniform abnormality. Mean normal percentage of Ia(+) T cells was 2.4% whereas 16 to 29 immunodeficient patients showed elevated proportions and absolute numbers of Ia(+) T cells. Striking fluctuation in proportions of Ia(+) T cells was noted in serial studies of five immunodeficient subjects in contrast to similar analyses of normal controls. A correlation (P less than 0.01) was recorded between absolute numbers of Ia(+) T cells in immune deficiency patients and numbers of T mu cells. Depletion of T gamma cells by EA rosetting in patients with late-onset primary acquired hypogammaglobulinaemia did not result in significant change in IgG or IgM synthesis with T gamma-depleted T cells were co-cultured with normal B cells. Depletion of Ia(+) T cells likewise did not significantly influence Ig synthesis in co-culture with normal or immune-deficient B cells. These studies emphasize the complexity of defects present among any large group of patients with immune deficiency.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-1086250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-1092499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-1261091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-135378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-158034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-163714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-300309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-301544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-303998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-305403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-306415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-309372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-309915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-314898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-330746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-4137918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-4564038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-466856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-53240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-6248281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-6444306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-68997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-75939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-792341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-804005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970642-89729
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
355-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6970642-Adult,
pubmed-meshheading:6970642-B-Lymphocytes,
pubmed-meshheading:6970642-Histocompatibility Antigens Class II,
pubmed-meshheading:6970642-Humans,
pubmed-meshheading:6970642-Immunoglobulin G,
pubmed-meshheading:6970642-Immunoglobulin M,
pubmed-meshheading:6970642-Immunoglobulins,
pubmed-meshheading:6970642-Immunologic Deficiency Syndromes,
pubmed-meshheading:6970642-Infant,
pubmed-meshheading:6970642-Receptors, Fc,
pubmed-meshheading:6970642-Rosette Formation,
pubmed-meshheading:6970642-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
T lymphocyte subpopulations and Ia-positive T cells in patients with immunodeficiency.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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