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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-4-24
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pubmed:abstractText |
The in vivo effects of BCG were studied on antibody-dependent cellular cytotoxicity (ADCC) using an assay in which the effectors were spleen cells of BCG-treated mice, and the targets antibody-coated chicken red blood cells (CRBC). In the study of the time course of action, an increased ADCC-activity was observed starting at day 10 with a maximum (four-fold augmentation) at day 14 after BCG treatment. The nature of the effector cell was investigated: in normal mice the activity was found in two cell populations, i.e. macrophages and theta-negative (theta-) nylon-adherent spleen cells. A BCG treatment increased the ADCC activity of macrophages of theta- nylon-adherent spleen cells and induced a population of theta- nylon-non-adherent spleen cells. In old mice, the effects of BCG were compared after a weekly long-term (6 months) treatment and after administration of a single dose. It was concluded that ADCC is higher in old mice than in young mice and can be further increased by treatment with a single dose of BCG in contrast with the long-term treatment which impaired this immune reaction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-1079853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-1087314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-334381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4182654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4312660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4377709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4659050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4692859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-4792349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-52180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-803302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-807647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-894742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-903182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6970164-904001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
687-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6970164-Aging,
pubmed-meshheading:6970164-Animals,
pubmed-meshheading:6970164-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:6970164-BCG Vaccine,
pubmed-meshheading:6970164-Cell Adhesion,
pubmed-meshheading:6970164-Cell Separation,
pubmed-meshheading:6970164-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6970164-Erythrocytes,
pubmed-meshheading:6970164-Female,
pubmed-meshheading:6970164-Kinetics,
pubmed-meshheading:6970164-Macrophages,
pubmed-meshheading:6970164-Mice,
pubmed-meshheading:6970164-Mice, Inbred Strains,
pubmed-meshheading:6970164-Spleen,
pubmed-meshheading:6970164-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
Study of the effect of single or multiple doses of BCG on antibody-dependent cellular cytotoxicity.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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