Linked Life Data

6969697

Source:http://linkedlifedata.com/resource/pubmed/id/6969697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-3-17
pubmed:abstractText
In three human cells lines, X-irradiation damage to DNA is quantitatively repaired in 2 hours or less. At 4 hours following single doses of 1000 rad or less, delayed or latent damage to the DNA appears in CCRF-CEM and 8402 leukaemia cells; HeLa cells under these conditions demonstrate comparatively little such post-repair DNA damage. With larger doses (2000-8000 rad), DNA in HeLa cells also exhibits post-repair damage. This damage is in the form of small acid-precipitable, double-stranded DNA fragments, and is demonstrated by batch elution from hydroxylapatite and alkaline and neutral sucrose sedimentation velocity techniques. The appearance of delayed DNA damage may be an early, critical expression of radiation-induced cytotoxic progression because the lesions are dose-dependent and are apparently not repaired.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7616
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Post-repair DNA damage in X-irradiated cultured human tumour cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.