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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1981-2-19
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pubmed:abstractText |
The pathogenesis of hypersensitivity pneumonitis is incompletely understood; cell-mediated hypersensitivity mechanisms may be involved, but in vitro correlates have been studied in humans with inconclusive results. We used a rabbit model of hypersensitivity pneumonitis to study systemic and local antigen-specific lymphocyte responses as measured by in vitro incorporation of 3H-thymidine. Groups of animals were systemically immunized with ovalbumin and acutely or repeatedly challenged with aerosolized ovalbumin. Lymphocyte responses were measured in peripheral blood, mediastinal and popliteal lymph nodes, bronchus-associated lymphoid tissue, and bronchoalveolar wash fluids in these groups and in appropriate control animals. Lymphocyte proliferative responses to specific antigen, shown previously to be a T-cell response in this system, occurred after systemic or inhalation exposure to antigen. Acute alveolitis was associated with a decrease in peripheral blood lymphocyte responses and the presence of responsive lymphocytes in bronchoalveolar was fluids. Repeated inhalation challenge thrice weekly for 1 month, with waning of alveolitis, was not associated with significant changes in lymphocyte responsiveness. Antigen-specific lymphocyte blastogenesis did not define animals capable of developing alveolitis after aerosol challenge and did not appear, therefore, to distinguish effector cell activity in this model.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0003-0805
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
122
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
761-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6969562-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:6969562-Animals,
pubmed-meshheading:6969562-Antigens,
pubmed-meshheading:6969562-Female,
pubmed-meshheading:6969562-Lymphocyte Activation,
pubmed-meshheading:6969562-Male,
pubmed-meshheading:6969562-Rabbits,
pubmed-meshheading:6969562-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
Systemic and local lymphocyte responses in experimental hypersensitivity pneumonitis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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