| pubmed-article:6969150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6969150 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6969150 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:6969150 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:6969150 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:6969150 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6969150 | pubmed:dateCreated | 1981-2-19 | lld:pubmed |
| pubmed-article:6969150 | pubmed:abstractText | Peripheral blood mononuclear cells from thirty-one patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease) were analysed for the proportions and absolute numbers of total T cells, and for the T cell subpopulations carrying Fc receptors for either IgM (Tmu cells) or IgG (T gamma cells). Twenty-six control subjects were studied simultaneously. Total T cell numbers were normal in patients with inflammatory bowel disease but there was a marked reduction in the proportion and absolute numbers of Tmu cells in patients, whether their disease was active or in remission. T gamma cells were normal. Simultaneous assessment of lymphocyte response to mitogens in vitro was performed in a group of patients. Responses to phytohaemagglutinin, concanavalin A and pokeweed mitogen were decreased and a positive correlation was found between the number of circulating Tmu cells and the responses to mitogens in vitro. These studies demonstrate that despite the presence of normal numbers of total T cells in inflammatory bowel disease, there is a marked imbalance in T cell subpopulations that correlates with mitogen responsiveness. This imbalance provides a possible cellular basis for the defect in cell-mediated immunity seen in these patients. | lld:pubmed |
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| pubmed-article:6969150 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6969150 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6969150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6969150 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6969150 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:6969150 | pubmed:author | pubmed-author:HodgsonH JHJ | lld:pubmed |
| pubmed-article:6969150 | pubmed:author | pubmed-author:VictorinoR... | lld:pubmed |
| pubmed-article:6969150 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6969150 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:6969150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6969150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6969150 | pubmed:pagination | 156-65 | lld:pubmed |
| pubmed-article:6969150 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6969150 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6969150 | pubmed:articleTitle | Alteration in T lymphocyte subpopulations in inflammatory bowel disease. | lld:pubmed |
| pubmed-article:6969150 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6969150 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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