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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-2-19
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pubmed:abstractText |
Peripheral blood mononuclear cells from thirty-one patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease) were analysed for the proportions and absolute numbers of total T cells, and for the T cell subpopulations carrying Fc receptors for either IgM (Tmu cells) or IgG (T gamma cells). Twenty-six control subjects were studied simultaneously. Total T cell numbers were normal in patients with inflammatory bowel disease but there was a marked reduction in the proportion and absolute numbers of Tmu cells in patients, whether their disease was active or in remission. T gamma cells were normal. Simultaneous assessment of lymphocyte response to mitogens in vitro was performed in a group of patients. Responses to phytohaemagglutinin, concanavalin A and pokeweed mitogen were decreased and a positive correlation was found between the number of circulating Tmu cells and the responses to mitogens in vitro. These studies demonstrate that despite the presence of normal numbers of total T cells in inflammatory bowel disease, there is a marked imbalance in T cell subpopulations that correlates with mitogen responsiveness. This imbalance provides a possible cellular basis for the defect in cell-mediated immunity seen in these patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969150-1081463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969150-1084844,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6969150-Adolescent,
pubmed-meshheading:6969150-Adult,
pubmed-meshheading:6969150-Aged,
pubmed-meshheading:6969150-Colitis, Ulcerative,
pubmed-meshheading:6969150-Crohn Disease,
pubmed-meshheading:6969150-Humans,
pubmed-meshheading:6969150-Immunoglobulin G,
pubmed-meshheading:6969150-Immunoglobulin M,
pubmed-meshheading:6969150-Leukocyte Count,
pubmed-meshheading:6969150-Lymphocyte Activation,
pubmed-meshheading:6969150-Middle Aged,
pubmed-meshheading:6969150-Mitogens,
pubmed-meshheading:6969150-Receptors, Fc,
pubmed-meshheading:6969150-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
Alteration in T lymphocyte subpopulations in inflammatory bowel disease.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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