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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1981-1-26
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pubmed:abstractText |
In 30 patients with systemic lupus erythematosus the number of a circulating basophils was countered in different stages of activity. An inverse correlation was found between the absolute basophils count and anti-DNA antibodies and presumptive circulating immune complexes (as judged by polyethylene glycol precipitation of serum). A positive correlation was found between the absolute basophil count and C3 or C4 levels. IgE on the basophil surface was determined by radioimmunoassay in 7 patients. All of them showed a significantly higher surface IgE number. When the count of circulating basophils was roughly normal, 5 out of the 6 patients showed a positive basophil degranulation test with native DNA. These results suggest the existence of an anti-DNA specific IgE in lupus patients. Depression of the circulating basophil count may be a useful index of lupus activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-1009682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-14014160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-16590216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4099713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4106804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4118412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4123821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4137310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4604875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4864670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-4956917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-55986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-56775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-631917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-66241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-69817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-71519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6969064-881555
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0003-4967
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
312-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6969064-Antibodies, Antinuclear,
pubmed-meshheading:6969064-Antigen-Antibody Complex,
pubmed-meshheading:6969064-Basophils,
pubmed-meshheading:6969064-Complement System Proteins,
pubmed-meshheading:6969064-DNA,
pubmed-meshheading:6969064-Humans,
pubmed-meshheading:6969064-Hypersensitivity, Immediate,
pubmed-meshheading:6969064-Immunoglobulin E,
pubmed-meshheading:6969064-Leukocyte Count,
pubmed-meshheading:6969064-Lupus Erythematosus, Systemic
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pubmed:year |
1980
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pubmed:articleTitle |
Evidence of an immediate hypersensitivity mechanism in systemic lupus erythematosus.
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pubmed:publicationType |
Journal Article
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