Linked Life Data

6968294

Source:http://linkedlifedata.com/resource/pubmed/id/6968294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-12-16
pubmed:abstractText
The role of T cells in the IgE antibody response was studied using athymic nu/nu mice which failed to form IgE antibody against either T-dependent or T-independent antigens. Evidence was obtained that hapten-specific B cells can be primed with T-dependent or T-independent antigens in the absence of T cells. Transfer of nu/nu spleen cells primed with alum-absorbed dinitrophenyl (DNP) ovalbumin or DNP derivatives of Salmonella bacilli into irradiated nu/+ mice, together with unprimed T cells, enhanced IgE antihapten antibody response of the recipients to alum-absorbed DNP-KLH. The antigen-primed nu/nu spleen cells, however, did not contain hapten-specific B memory cells directly committed to IgE response, since no antihapten IgE antibody response was obtained when the same DNP-primed nu/nu spleen cells were transferred into irradiated mice, together with KHL-primed nu/+ spleen cells, and the recipients were challenged with DNP-KLH without adjuvant. Once IgE-B memory cells responded to DNP derivatives of both T-dependent and T-independent carriers to form a significant amount of antihapten IgE antibody without participation of T cells. The results indicate that the essential role of T helper cells in the IgE antibody response is in the process of the development of IgE-B memory cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
284-93
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
T cell dependent and independent steps in IgE-B memory cell development.
pubmed:publicationType
Journal Article