Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-9-29
|
| pubmed:abstractText |
Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
136
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
17-25
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:69670-Animals,
pubmed-meshheading:69670-Cold Temperature,
pubmed-meshheading:69670-Epitopes,
pubmed-meshheading:69670-Ferrets,
pubmed-meshheading:69670-Hemagglutination Inhibition Tests,
pubmed-meshheading:69670-Humans,
pubmed-meshheading:69670-Influenza A virus,
pubmed-meshheading:69670-Influenza Vaccines,
pubmed-meshheading:69670-Orthomyxoviridae,
pubmed-meshheading:69670-Recombination, Genetic,
pubmed-meshheading:69670-Vaccines, Attenuated
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|