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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0004561,
umls-concept:C0005516,
umls-concept:C0020200,
umls-concept:C0020204,
umls-concept:C0023158,
umls-concept:C0086418,
umls-concept:C0205369,
umls-concept:C1327616,
umls-concept:C1441547,
umls-concept:C1704788
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pubmed:issue |
2
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pubmed:dateCreated |
1980-9-23
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pubmed:abstractText |
A hybridoma has been isolated from the products of fusion of a myeloma cell line with spleen cells from mice immunized with a human B cell line. After cloning, the hybridoma secretes antibody with the following properties: (i) Human B-lymphoblastoid cell lines react with the antibody while T and null cell lines do not. (ii) The antibody reacts with the majority of leucocytes in the blood of patients with CLL, but with a minority of cells in the blood of patients with AML or ALL of the null or T type. (iii) The antibody reacts with 9-21% of mononuclear cells in normal peripheral blood. The reacting cells are not T cells and overlap extensively with cells identified as B cells by other markers. The antigen identified by this antibody appears to be distinct from known B cell markers, and is put forward as a new B cell marker with diagnostic potential.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1083525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1083873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1086250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1086826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1087215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1102600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1107571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-135378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-304074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-307583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-355550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-367654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-404738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4113510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4132264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4149580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4546446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4577736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4585857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-4607056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-46882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-52313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-558524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-567552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-567556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-775683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-778323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6966995-84723
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-9104
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
477-85
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6966995-Animals,
pubmed-meshheading:6966995-Antibody Specificity,
pubmed-meshheading:6966995-Antibody-Producing Cells,
pubmed-meshheading:6966995-Antilymphocyte Serum,
pubmed-meshheading:6966995-B-Lymphocytes,
pubmed-meshheading:6966995-Clone Cells,
pubmed-meshheading:6966995-Humans,
pubmed-meshheading:6966995-Hybrid Cells,
pubmed-meshheading:6966995-Male,
pubmed-meshheading:6966995-Mice,
pubmed-meshheading:6966995-Mice, Inbred BALB C,
pubmed-meshheading:6966995-Multiple Myeloma,
pubmed-meshheading:6966995-Receptors, Antigen, B-Cell,
pubmed-meshheading:6966995-Spleen
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pubmed:year |
1980
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pubmed:articleTitle |
Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. I. A hybridoma secreting antibody against a marker specific for human B lymphocytes.
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pubmed:publicationType |
Journal Article
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