Linked Life Data

6965464

Source:http://linkedlifedata.com/resource/pubmed/id/6965464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-4-23
pubmed:abstractText
Immunotherapy with daily intradermal injections of OK-432, penicillin- and heat-treated lyophilized powder of Su-strain of streptococcus pyogens A3, for over a period of four weeks resulted in quantitative and qualitative effectiveness on impaired cell-mediated immunity even in many patients with far advanced cancer of the stomach or lung. In vitro lymphocyte studies following immunotherapy with OK-432 demonstrated restoration of circulating lymphocyte counts to more than 1,500/microliters, a level associated with normalized subpopulation constitution and increases of phytomitogen blastogenesis. Furthermore, a delayed hypersensitivity skin reaction to PPD was boosted or converted into a positive reaction in some cases. There was, however, no detectable, definite effect on humoral immunity after the therapy. Survival rates at three and six months after the initiation of immunochemotherapy using OK-432 and another chemotherapeutic agent, 5-fluorouracil, in 40 patients with cancer were significantly longer than those of matched control patients given chemotherapy alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-543X
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
476-83
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Clinical studies on cell-mediated immunity in patients with malignant disease. I. Effect of immunotherapy with OK-432 on lymphocyte subpopulation and phytomitogen responsiveness in vitro.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro