Linked Life Data

6962833

Source:http://linkedlifedata.com/resource/pubmed/id/6962833

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1983-5-5
pubmed:abstractText
Aclacinomycin A (ACM) antisera were obtained from the rabbits immunized with 4"'-deoxo-4"'-(R)-amino-ACM- or N,N-didemethyl-ACM-bovine serum albumin conjugate, and their immunoreactivities were tested with ACM-related anthracyclines. It was found that the binding ability with the ACM antisera was markedly decreased by the following structural changes in ACM: N,N-didemethylation of the rhodosamine moiety; 6-O- or 4-O-methylation; removal of the methoxycarbonyl group at C-10; hydroxylation at C-1, C-2 or C-11. It was less affected by some alterations in a side chain at C-9 or by deglycosidation of the terminal mono or disaccharide. The binding of the aglycone (aklavinone) was very weak.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0386-846X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
886-92
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Immunological cross-reactivities of various anthracycline antibiotics against aclacinomycin A antisera.
pubmed:publicationType
Journal Article