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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1983-1-27
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pubmed:abstractText |
A DNA sequence that generates aberrantly rearranged immunoglobulin heavy chain constant region genes in murine plasmacytomas is shown to participate in a chromosome translocation. We have previously termed this DNA sequence NIARD for non-immunoglobulin-associated rearranging DNA. NIARD rearrangements were found frequently in murine plasmacytomas but were not detected in normal lymphocytes. These rearrangements occasionally involve the switch region of the C alpha gene. In this study, DNA samples obtained from mouse-Chinese hamster somatic cell hybrid lines were digested with various restriction endonucleases and analyzed by the Southern transfer technique with a NIARD hybridization probe. These experiments show that NIARD resides on chromosome 15 in the mouse germ line. Since NIARD is found adjacent to the C alpha gene (located on chromosome 12) in some plasmacytomas, it is apparent that a translocation involving these two chromosomes has occurred. We have proposed a rcpT(12;15) model to explain our data. The implications of NIARD rearrangements for malignant transformation are discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-100225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-100427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-1055422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-111144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-111241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-115000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-209203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-212501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-216842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-269444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-291033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-4113130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-4126434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-4423652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-519762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6265582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6272118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6278424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6287471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6454740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6766206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6766810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6767238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6767246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6769113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6769593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6770027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6774258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6774415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6781756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6791031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6793874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6801764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6806666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-6976417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-7276830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-7312030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-7444720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-90020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-946170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-97665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6959142-994195
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6622-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6959142-Animals,
pubmed-meshheading:6959142-Chromosome Mapping,
pubmed-meshheading:6959142-Gene Expression Regulation,
pubmed-meshheading:6959142-Genes,
pubmed-meshheading:6959142-Immunoglobulins,
pubmed-meshheading:6959142-Mice,
pubmed-meshheading:6959142-Neoplasms, Experimental,
pubmed-meshheading:6959142-Plasmacytoma,
pubmed-meshheading:6959142-Translocation, Genetic
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pubmed:year |
1982
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pubmed:articleTitle |
DNA sequence associated with chromosome translocations in mouse plasmacytomas.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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