Linked Life Data

6958913

Source:http://linkedlifedata.com/resource/pubmed/id/6958913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-1-27
pubmed:abstractText
The carcinogenic effect of carbazole (9H-carbazole) in (C57BL/6N X C3H/HeN)F1 (B6C3F1) mice was examined. Groups of 50 mice of both sexes were given a basal diet containing 0.6, 0.3, or 0.15% carbazole for 96 weeks and were then placed on an unsupplemented basal diet until they were killed at week 104. Mice surviving longer than 52 weeks were included in effective numbers. Significant increases in the induction of neoplastic lesions were found in the livers and forestomachs of mice given carbazole as compared to the control groups. The lesions in the livers were classified into two types, neoplastic nodules or hepatocellular carcinomas. The incidences of both types of lesions were almost 100% in mice treated with carbazole, and both types of lesions were significantly increased in all mice except the males given 0.6% carbazole in their diet. The incidences of hepatocellular carcinomas were in general higher than those of neoplastic nodules. Though not statistically significant, increased incidences of pulmonary metastases were found in the groups given carbazole. Significantly increased incidences of neoplastic lesions and papillomas in the forestomach in all groups of female and male mice were also noted in the mice fed 0.6% carbazole. Squamous cell carcinoma induction was significantly different in male mice given 0.6% carbazole as compared to controls. These results indicate that carbazole is carcinogenic to the liver and forestomach in B6C3F1 mice and suggest that carbazole may be an environmental carcinogen relevant to cancer risk in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1383-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Carcinogenic effect of carbazole in the liver of (C57BL/6N x C3H/HeN)F1 mice.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't