Linked Life Data

6956716

Source:http://linkedlifedata.com/resource/pubmed/id/6956716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1982-12-2
pubmed:abstractText
Ten potential adjuvants for rectal absorption which are structurally similar to salicylate have been examined using an in situ perfusion of the rat rectum technique as well as an in vivo absorption method from microenemas. All of the adjuvants studied readily disappeared from the perfusate at pH 4.5; however, several were not absorbed well at pH 7.4. Only those that were lost rapidly from the perfusate at pH 7.4 were effective in enhancing the disappearance of the drugs (theophylline, lidocaine, cefmetazole, and levodopa) at either a pH of 4.5 or 7.4. The compounds that were effective in promoting the disappearance of drugs from the rectal perfusate all had hydroxy and carboxy groups. Those substances lacking a hydroxy group were not effective. The binding of these potential adjuvants and salicylates to rat rectum tissue was studied by equilibrium dialysis. Those adjuvants with relatively high binding to rat rectal tissue were better absorbed themselves and promoted the disappearance of drugs more than those substances exhibiting little binding. Thus, adjuvant binding to some feature of the rectal membrane appears to be important in the enhanced absorption of drugs from the rectum under the conditions of this study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
865-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Enhanced rectal absorption of theophylline, lidocaine, cefmetazole, and levodopa by several adjuvants.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't