rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1982-10-21
|
pubmed:abstractText |
17 (S)methyl-omega-homo trans delta 2 PGE1 (ONO 1206) an analogue of PGE1 was studied on vasopressin-induced ECG changes in four male monkeys and three female baboons. Bolus intravenous doses of vasopressin (0.8 I.U. to 1.0 I.U./kg) produced flattening of the T wave (2 monkeys) elevation of ST segment (1 baboon and 1 monkey) and inversion of T wave (1 baboon). Inverted T waves were also present in one baboon and one monkey prior to any drug administration. In four out of seven animals, boLus intravenous doses (5 to 15 micrograms/kg) of ONO 1206 reversed the ECG changes produced by vasopressin and in one animal ONO 1206 reversed the existing inverted T wave. These findings indicate that vasopressin is a suitable agent for the induction of coronary vasoconstriction in primates and that ONO 1206 is able to reverse this effect.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0262-1746
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
343-8
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6955802-Alprostadil,
pubmed-meshheading:6955802-Animals,
pubmed-meshheading:6955802-Blood Pressure,
pubmed-meshheading:6955802-Coronary Circulation,
pubmed-meshheading:6955802-Electrocardiography,
pubmed-meshheading:6955802-Female,
pubmed-meshheading:6955802-Macaca mulatta,
pubmed-meshheading:6955802-Male,
pubmed-meshheading:6955802-Papio,
pubmed-meshheading:6955802-Prostaglandins E, Synthetic,
pubmed-meshheading:6955802-Vasoconstriction,
pubmed-meshheading:6955802-Vasodilator Agents,
pubmed-meshheading:6955802-Vasopressins
|
pubmed:year |
1982
|
pubmed:articleTitle |
Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|