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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1982-2-25
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pubmed:abstractText |
Various sulfonic acid derivatives of 1-naphthylamine and 2-naphthylamine were tested in inbred A/St (male and female) mice by the pulmonary adenoma bioassay to determine if this class of compounds, used as intermediates in the dye-stuff industry, possesses tumorigenic activity. Neither 1-naphthylamine nor the four sulfonic acid derivatives of 1-naphthylamine tested were tumorigenic. However, 2-naphthylamine and two of the three sulfonic acid derivatives of 2-naphthylamine tested produced statistically significant lung tumor responses at comparable doses. These results indicated that this class of compounds should be examined more extensively for carcinogenic activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8874
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1299-302
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6947112-1-Naphthylamine,
pubmed-meshheading:6947112-2-Naphthylamine,
pubmed-meshheading:6947112-Adenoma,
pubmed-meshheading:6947112-Animals,
pubmed-meshheading:6947112-Coloring Agents,
pubmed-meshheading:6947112-Female,
pubmed-meshheading:6947112-Lung Neoplasms,
pubmed-meshheading:6947112-Male,
pubmed-meshheading:6947112-Mice,
pubmed-meshheading:6947112-Mice, Inbred A,
pubmed-meshheading:6947112-Naphthalenes,
pubmed-meshheading:6947112-Sulfonic Acids
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pubmed:year |
1981
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pubmed:articleTitle |
Pulmonary adenoma response of strain A mice to sulfonic acid derivatives of 1- and 2-naphthylamines.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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