Linked Life Data

6947016

Source:http://linkedlifedata.com/resource/pubmed/id/6947016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-2-22
pubmed:abstractText
Four monocyte functions were studied in patients with pulmonary tuberculosis and in healthy subjects. Circulating monocytes from four of six patients with tuberculosis functioned as suppressor cells; depletion of adherent cells from mononuclear cells obtained from the peripheral blood of these patients resulted in a 37-fold enhancement in tuberculin purified protein derivative-induced incorporation of [3H]thymidine. Monocytes from patients with tuberculosis exhibited increased adherence to plastic. Plasma from patients with tuberculosis also increased the adherence of monocytes from healthy subjects. However, basal and lipopolysaccharide-stimulated production of prostaglandin E2 by monocytes and tumoricidal activity were not altered in patients with tuberculosis. Thus, tuberculosis in humans is associated with the enhancement of selective monocyte functions. The dissociation in monocyte effector functions in human mycobacterial infection has potential implications not only for the course of tuberculosis but also for immunoadjuvant therapy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Augmentation of selective monocyte functions in tuberculosis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.