Linked Life Data

6944555

Source:http://linkedlifedata.com/resource/pubmed/id/6944555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-11-22
pubmed:abstractText
The intestinal microflora has been shown to influence the induction of chemical carcinogens responsible for intestinal tumors in animal models. For further exploration of this issue, male inbred F344 rats were administered a chemical carcinogen, 1,2-dimethylhydrazine dihydrochloride (DMH), for 20 weeks, along with oral antibiotics, either tetracycline or erythromycin, to suppress the intestinal flora. Colon cancer incidence was lower in animals receiving antibiotics; 22% of the erythromycin-treated rats and 20% of the tetracycline-treated rats had colon tumors compared to untreated controls with a 74% tumor incidence (P less than 0.002). Tumors in the small intestine also decreased from an incidence of 48% in the control animals to an incidence of 27 and 7%, respectively, for the erythromycin- and tetracycline-treated rats. These findings suggested that the metabolic activity of the intestinal flora is related to cancer induction by DMH.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
877-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effect of antibiotics on incidence of rat intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't