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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-9-15
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pubmed:abstractText |
The form of 125I-labeled membrane alloantigens (I-Ak and H-2Kk) and immunoglobulin M shed by murine splenic lymphocytes labeled by lactoperoxidase-catalyzed radioiodination was determined by gel chromatography and ultracentrifugation. I-Ak and H-2Kk antigens are shed as particles ranging in size from 3 X 10(5) to 2 X 10(6), whereas membrane IgM is shed as an individual unit consonant with its native size of 180,000. The effects of detergents on the size of shed I-Ak and H-2Kk and the coprecipitation of (3H) lipids with these proteins suggest that I-Ak and H-2Kk are shed in association with local membrane lipids as small membrane-derived vesicles, whereas membrane IgM is shed without detectable associated lipid.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
482-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6942054-Animals,
pubmed-meshheading:6942054-Chromatography, Gel,
pubmed-meshheading:6942054-Chromatography, Thin Layer,
pubmed-meshheading:6942054-Chymotrypsinogen,
pubmed-meshheading:6942054-H-2 Antigens,
pubmed-meshheading:6942054-Histocompatibility Antigens Class II,
pubmed-meshheading:6942054-Immunoglobulin G,
pubmed-meshheading:6942054-Macromolecular Substances,
pubmed-meshheading:6942054-Membrane Lipids,
pubmed-meshheading:6942054-Mice,
pubmed-meshheading:6942054-Mice, Inbred CBA,
pubmed-meshheading:6942054-Molecular Weight,
pubmed-meshheading:6942054-Ovalbumin,
pubmed-meshheading:6942054-Ultracentrifugation
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pubmed:year |
1981
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pubmed:articleTitle |
I-Kk and H-2Kk antigens are shed as supramolecular particles in association with membrane lipids.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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