|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1981-9-15
|
|
pubmed:abstractText |
Demethoxycarbonyl derivatives of aclacinomycin A and of its 7-epimer, 10-epi-aclacinomycin A and 4-O-methylaclacinomycin A were chemically derived from aclacinomycin A. The cytotoxicity and inhibitory effects of RNA and DNA synthesis in cultured L1210 leukemia cells of the 4-O-methyl derivative approximated that of aclacinomycin A, while the demethoxycarbonyl derivatives and 10-epi-aclacinomycin A exhibited decreased activities in comparison with the parent compound.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0021-8820
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
33
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1323-30
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:6941951-Aclarubicin,
pubmed-meshheading:6941951-Animals,
pubmed-meshheading:6941951-Cell Survival,
pubmed-meshheading:6941951-Cells, Cultured,
pubmed-meshheading:6941951-Chemical Phenomena,
pubmed-meshheading:6941951-Chemistry,
pubmed-meshheading:6941951-DNA, Neoplasm,
pubmed-meshheading:6941951-Depression, Chemical,
pubmed-meshheading:6941951-Leukemia L1210,
pubmed-meshheading:6941951-Methylation,
pubmed-meshheading:6941951-Molecular Conformation,
pubmed-meshheading:6941951-Naphthacenes,
pubmed-meshheading:6941951-RNA, Neoplasm,
pubmed-meshheading:6941951-Structure-Activity Relationship
|
|
pubmed:year |
1980
|
|
pubmed:articleTitle |
Chemical modification of anthracycline antibiotics. I. Demethoxycarbonylation, 10-epimerization and 4-o-methylation of aclacinomycin A.
|
|
pubmed:publicationType |
Journal Article
|
