Linked Life Data

6941604

Source:http://linkedlifedata.com/resource/pubmed/id/6941604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-8-20
pubmed:abstractText
The local vasoconstrictor response to increased venous transmural pressure was studied in the forefoot in 18 normal subjects and in 43 patients with occlusive arterial disease of the lower limbs. Subcutaneous blood flow was measured by the local 133-Xenon wash-out technique. Blood flow measured 40 cm below heart level was compared to blood flow measured at heart level. In 18 normal limbs the vasoconstrictor response caused a decrease in blood flow to a median value of 73%, compared to a median value of 88% in 22 limbs with intermittent claudication without rest pain (p = 0.01). In limbs with ischemic symptoms at rest blood flow increased to a median value of 1.36, when the leg was lowered. Assuming that arterial and venous transmural pressures increase equally during lowering, corresponding to the hydrostatic pressure, keeping the perfusion pressure constant, then the changes in blood flow are due to changes in local peripheral resistance. The significantly smaller decrease in blood flow in claudicants is thus interpreted being due to a functional or structural adaptation of the arterioles to the chronic hypotension. The increase in blood flow during lowering in limbs with rest pain implies a diminished peripheral resistance caused by passive dilation of the arterioles by the increased transmural pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-1860
pubmed:author
pubmed:issnType
Print
pubmed:volume
502
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-14
pubmed:dateRevised
2007-12-6
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Forefoot vasoconstrictor response to increased venous pressure in normal subjects and in arteriosclerotic patients.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't