Linked Life Data

6941387

Source:http://linkedlifedata.com/resource/pubmed/id/6941387

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-8-27
pubmed:abstractText
Several potentially harmful agents present in the gastric juice or duodenal contents were assessed in terms of their ability to cause damage to the esophageal mucosa using an in vitro technique. In the presence of luminal acid (pH 3.5), taurocholate and pepsin and, to a lesser degree, lysolecithin adversely affected the mucosa causing increased diffusion of luminal H+ into the mucosa, a mechanism which may play a significant role in the pathogenesis of acidic reflux esophagitis. In the absence of luminal acid (pH 7.4) trypsin and the deconjugated bile salts cholate, chenodeoxycholate and deoxycholate affected the mucosa and possibly play a more important role in the pathogenesis of alkaline reflux esophagitis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0085-5928
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-21
pubmed:dateRevised
2008-2-13
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effect of bile salts and related compounds on esophageal mucosa.
pubmed:publicationType
Journal Article, In Vitro