Linked Life Data

6940415

Source:http://linkedlifedata.com/resource/pubmed/id/6940415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-7-20
pubmed:abstractText
Biological screening of dental materials which are intended for use in contact with the oral mucosa comprises a mucous membrane irritation test. The aim of the present investigation was to study the effect of 3 periodontal dressings on intact oral mucosa and to assess their effect on the epithelial proliferation during wound healing. A total of 87 rats were used, 24 for studying reactions in intact mucosa and 63 for a wound healing study. A wound was inflicted on each animal in the palate behind the incisors. The dressing covered the wound area and the surrounding mucosa and was secured by an appliance fixed to the maxillary incisors. 3H-labelled thymidine was injected prior to sacrifice after observation periods of 1, 3 and 5 days. Histological assessment and autoradiographic evaluation of mitotic activity were performed. The dressings caused no reaction in the intact mucosa. In the wound healing study the mitotic activity at day 1 was lower in test than in control animals indicating a toxic effect of all materials. No differences between the 3 dressings were found. After 5 days, all wounds were covered by epithelium. Neither at 3 nor at 5 days were any differences between test and control animals seen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:status
MEDLINE
pubmed:issn
0001-6357
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-70
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The effect of periodontal dressings on intact mucous membrane and on wound healing. A methodological study.
pubmed:publicationType
Journal Article