Linked Life Data

6939922

Source:http://linkedlifedata.com/resource/pubmed/id/6939922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-7-20
pubmed:abstractText
The covalent interactions between aflatoxin B1 (AFB1) and DNA were investigated in the inbred F344 rat and noninbred CD -1 Swiss mouse. A good correlation was found between the level of covalent modification of DNA, species sensitivity, and organ specificity, to the toxic effects of AFB1. The patterns of AFB1 acid hydrolysis products from DNA isolated from the livers and kidneys of both species were examined. The principal acid hydrolysis product in all cases was identified as 2,3-dihydro-3-hydroxy-(N7-guanyl)AFB1. Minor products consisted of adducts formed by the chemical transformation of the AFB1-N7-substituted guanine moiety forming putative formamidopyrimidine derivatives and the activation of AFB1 metabolites, which also modified the N-7 guanine atom. These last-mentioned products were present in greater amounts in resistant tissues. In vitro studies on the activation of AFB1 by microsomal fractions of mouse and rat livers found that mouse liver microsomes were rapidly inactivated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
761-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Quantitative comparison of covalent aflatoxin-DNA adducts formed in rat and mouse livers and kidneys.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.