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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1981-1-29
|
| pubmed:abstractText |
The influence of dopaminergic modifiers on morphine-induced analgesia and lethality was studied comparing both the effect of a single pre-dose of haloperidol and and continuous pretreatment for three weeks with haloperidol. A single administration of haloperidol enhanced morphine-induced analgesia probably due to the receptor blocking action of haloperidol which supports the reduction of dopamine release produced by morphine. The daily haloperidol administration for 3 weeks however decreased the analgesic action of morphine in consequence of a dopamine receptor supersensitivity developed in this time. The lethality was increased under both conditions. These results suggest that the dopaminergic system, dependent upon its sensitivity, plays a modulating role in morphine-induced analgesia, but not in morphine-induced lethality.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0171-9750
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
471-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6933966-Analgesics,
pubmed-meshheading:6933966-Animals,
pubmed-meshheading:6933966-Dopamine,
pubmed-meshheading:6933966-Dose-Response Relationship, Drug,
pubmed-meshheading:6933966-Drug Interactions,
pubmed-meshheading:6933966-Female,
pubmed-meshheading:6933966-Haloperidol,
pubmed-meshheading:6933966-Morphine,
pubmed-meshheading:6933966-Rats
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
The influence of haloperidol pretreatment on the morphine toxicity.
|
| pubmed:publicationType |
Journal Article
|