Linked Life Data

6933570

Source:http://linkedlifedata.com/resource/pubmed/id/6933570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1981-1-29
pubmed:abstractText
Ionizing radiation has been used to selectively separate the circadian oscillator function of the eye of Aplysia from some of its other functions--synchronous compound action potential (CAP) generation, the light response, synaptic transmission between photoreceptors and output neurons, and the bursting pacemaker mechanism. Doses of 4-krad (50 kV peak) x-rays have a minimal effect on the circadian rhythm of CAP frequency, measured from the otpic nerve, whereas irradiation with a 40-krad dose abolishes the rhythm without affecting any of the four other functions of this eye (1 rad = 0.01 J/kg = 0.01/Gy). We estimate a 50% survival of the oscillator function at doses of about 6 krad. The oscillators of irradiated eyes are not merely desynchronized when the rhythm is abolished, because in vitro light-dark entrainment does not restore free-running rhythmicity. The results, including those from selective irradiation of the anterior or posterior poles of the eye, suggest that there are a number of circadian oscillators in the eye--most of them in the posterior portion near the optic nerve. An approximate target size has been obtained from target theory approximately equal to 10(8) A3, which is somewhat larger than the target size for viral infectivity function, as one example. There are reservations about estimating target size in a complex organ such as the eye. However, this approximate target size and the fact that recovery or repair can occur in vivo suggest that the oscillator may involve nucleic acid molecules.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-13631199, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-13675766, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-217016, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-284425, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-4348362, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-4355884, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-4556464, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-4818914, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-5047187, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-5119101, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-5647435, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-5761871, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-5778006, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-734049, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-862940, http://linkedlifedata.com/resource/pubmed/commentcorrection/6933570-993764
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5542-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The differential effects of ionizing radiation on the circadian oscillator and other functions in the eye of Aplysia.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.