Linked Life Data

6933278

Source:http://linkedlifedata.com/resource/pubmed/id/6933278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-1-29
pubmed:abstractText
Twenty-four-hour exposure of Friend leukemia (FL) and L1210 cells to 1.0 micrograms ellipticine/ml resulted in a slowdown in cell proliferation, accumulation of cells in G2 phase, an increase in cellular RNA content, and an increase in the proportion of cells with greater than 4C (tetraploid) content of DNA in both cell lines. Removal of the drug and subsequent cell culturing in fresh medium for 24 hours led to a further increase in the proportion of cells having more than a 4C content of DNA, with no change in cell number, in FL cell cultures. Distinct micronucleation and an increase in cell size without any sign of cell division were seen in FL cells so treated. In contrast, L1210 cells after transfer to fresh medium reentered the normal cell cycle, continued to proliferate, and demonstrated only a slight increase in cells with greater than a 4C content of DNA within 24 hours of removal of the drug.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1329-36
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Ellipticine-induced changes in cell growth and nuclear morphology.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.