|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1980-7-22
|
|
pubmed:abstractText |
Wild-type Brevibacterium flavum has been shown to possess arogenate dehydrogenase activity and to lack prephenate dehydrogenase, thereby providing presumptive evidence that arogenate (previously named "pretyrosine") is an obligatory intermediate of L-tyrosine biosynthesis. A similar enzymological pattern has been discerned in extracts made from wild-type cultures of various species of cyanobacteria. Application of rigorous molecular genetic criteria in confirmation of the exclusive role of arogenate in L-tyrosine synthesis was made possible by the isolation of an auxotrophic mutant exhibiting a nutritional requirement for L-tyrosine. The mutant was found to lack activity for arogenate dehydrogenase and to accumulate substantial amounts of arogenate behind the mutant block during starvation for L-tyrosine.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-123637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-13089663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-13168367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-13654249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-13989507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-144721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-16661043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-407230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-417080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-4206476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-4270797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-457594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-479120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-4958054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-500563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6929482-942051
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
77
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1270-3
|
|
pubmed:dateRevised |
2010-9-10
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1980
|
|
pubmed:articleTitle |
Arogenate (pretyrosine) is an obligatory intermediate of L-tyrosine biosynthesis: confirmation in a microbial mutant.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
