Linked Life Data

6919633

Source:http://linkedlifedata.com/resource/pubmed/id/6919633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-8-26
pubmed:abstractText
Effects of vanadate (NH4VO3: VAN) on tension development, membrane potential and cellular Na content were investigated in guinea-pig taenia coli depolarized by 62.7 mM KCl solution. VAN (10(-4) - 10(-3) M) caused a transient increase in the K developed tension followed by a relaxation. The VAN-induced contraction was observed even in a low Ca (0.13 mM) solution but was inhibited by the removal of external Ca. After the addition of verapamil (5 x 10(-8), 10(-7) M). VAN still produced a contraction. Further, the VAN-induced contraction was observed in 142.2 mM KCl (Na 11.9 mM) solution containing ouabain (10(-4) M). On the other hand, the effect of VAN to relax the K-induced contraction was dependent on the concentration of VAN. In low Na (choline-substituted) solution, the VAN-induced relaxation was decreased. VAN increased cellular Na content of the depolarized muscle, and a correlation was obtained between the cellular Na accumulation and the relaxation. These results suggest that the relaxation is mainly attributable to the accumulation of Na following the inhibition of the Na pump, while the contraction is independent of the inhibition of the Na pump and less sensitive to the external Ca than the K-induced process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-5198
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-57
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Dual actions of vanadate on high K-induced contraction in guinea-pig taenia coli.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't