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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1977-9-2
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pubmed:abstractText |
Spleen cells sensitized against trinitrophenyl (TNP)-modified stimulator cells displayed a cytotoxic effect against syngeneic TNP-modified but not dinitrophenyl (DNP)-modified target cells. The same finding was observed in the opposite direction; that is, effector cells sensitized against DNP-modified stimulator cells did not cross kill TNP-modified targets. The specificity of the anti-TNP effector cells was confirmed in a cold target competition assay. Presensitization in vivo with hapten-modified cells followed by rechallenge and testing in vitro did not alter the specificity of the response between the haptens. These data indicate that the receptor(s) on the cytotoxic T cell can distinguish between two closely related haptenic molecules.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-1079848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-1087327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-11993330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-13897619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-233899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-4108424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-4126771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-46185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-5124960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-52182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-52186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-52685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-58455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-58456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-58463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-62013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/69006-66272
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
600-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:69006-Animals,
pubmed-meshheading:69006-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:69006-Dinitrobenzenes,
pubmed-meshheading:69006-Epitopes,
pubmed-meshheading:69006-Haptens,
pubmed-meshheading:69006-Mice,
pubmed-meshheading:69006-Nitrobenzenes,
pubmed-meshheading:69006-Spleen,
pubmed-meshheading:69006-T-Lymphocytes,
pubmed-meshheading:69006-Trinitrobenzenes
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pubmed:year |
1977
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pubmed:articleTitle |
Cytotoxic T cells distinguish between trinitrophenyl- and dinitrophenyl-modified syngeneic cells.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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