Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-9-2
|
| pubmed:abstractText |
An experimental condition was established in vivo for selectively eliminating hapten-reactive suppressor T-cell activity generated in mice primed with a para-azobenzoate (PAB)-mouse gamma globulin (MGG)-conjugate and treated with PAB-nonimmunogenic copolymer of D-amino acids (D- glutamic acid and D-lysine; D-GL). The elimination of suppressor T-cell activity with PAB-D-GL treatment from the mixed populations of hapten- reactive suppressor and helper T cells substantially increased apparent helper T-cell activity. Moreover, the inhibition of PAB-reactive suppressor T-cell generation by the pretreatment with PAB-D-GL before the PAB-MGG-priming increased the development of PAB-reactive helper T-cell activity. The analysis of hapten-specificity of helper T cells revealed that the reactivity of helper cells developed in the absence of suppressor T cells was more specific for primed PAB-determinants and their cross-reactivities to structurally related determinants such as meta-azobenzoate (MAB) significantly decreased, as compared with the helper T-cell population developed in the presence of suppressor T lymphocytes. In addition, those helper T cells generated in the absence of suppressor T cells were highly susceptible to tolerogenesis by PAB-D- GL. Similarly, the elimination of suppressor T lymphocytes also enhanced helper T-cell activity in a polyclonal fashion in the T-T cell interactions between benzylpenicilloyl (BPO)-reactive T cells and PAB- reactive T cells after immunization of mice with BPO-MGG-PAB. Thus inhibition of BPO-reactive suppressor T-cell development by the BPO-v-GL- pretreatment resulted in augmented generation of PAB-reactive helper T cells with higher susceptibility of tolerogenesis to PAB-D-GL. Thus, these results support the notion that suppressor T cells eventually suppress helper T-cell activity and indicate that the function of suppressor T cells related to helper T-cell development is to inhibit the increase in the specificity and apparent affinity of helper T cells in the primary immune response. The hapten-reactive suppressor and helper T lymphocytes are considered as a model system of T cells that regulate the immune response, and the potential applicability of this system to manipulating various T cell-mediated immune responses is discussed in this context.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-1078737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-1080181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-1083888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-1085324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-1101468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-241141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-4598645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-47899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-4900673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-52217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-52219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-58729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-61874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/68995-62012
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Azo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Dinitrophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Haptens,
http://linkedlifedata.com/resource/pubmed/chemical/Hemocyanin,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillin G,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Globulins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1007
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
146
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
91-106
|
| pubmed:dateRevised |
2010-6-22
|
| pubmed:meshHeading |
pubmed-meshheading:68995-Animals,
pubmed-meshheading:68995-Antibody Formation,
pubmed-meshheading:68995-Antibody-Producing Cells,
pubmed-meshheading:68995-Antigen-Antibody Reactions,
pubmed-meshheading:68995-Azo Compounds,
pubmed-meshheading:68995-Benzoates,
pubmed-meshheading:68995-Dinitrophenols,
pubmed-meshheading:68995-Glutamates,
pubmed-meshheading:68995-Haptens,
pubmed-meshheading:68995-Hemocyanin,
pubmed-meshheading:68995-Hemolytic Plaque Technique,
pubmed-meshheading:68995-Immune Tolerance,
pubmed-meshheading:68995-Immunization,
pubmed-meshheading:68995-Lysine,
pubmed-meshheading:68995-Mice,
pubmed-meshheading:68995-Penicillin G,
pubmed-meshheading:68995-Suppression, Genetic,
pubmed-meshheading:68995-T-Lymphocytes,
pubmed-meshheading:68995-gamma-Globulins
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. II. Selective inactivation of hapten-reactive suppressor T cells by hapten-nonimmunogenic copolymers of D-amino acids, and its application to the study of suppressor T-cell effect on helper T-cell development.
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| pubmed:publicationType |
Journal Article
|