Linked Life Data

6896429

Source:http://linkedlifedata.com/resource/pubmed/id/6896429

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-8-26
pubmed:abstractText
Dexamethasone palmitate was incorporated into a lipid emulsion (Intralipid, Intralipos) and was injected into rats, and its distribution in the organs and tissues and its anti-inflammatory effects were compared with those of free dexamethasone disodium phosphate. The distribution patterns of [3H] dexamethasone were markedly different between the 2 preparations in 3 hours after intravenous administration. Dexamethasone palmitate given as a lipid emulsion showed a much higher concentration in the blood, spleen, and inflamed tissues (carrageenan oedema), whereas dexamethasone sodium phosphate had a high concentration in the muscles. The anti-inflammatory activity of both preparations given intravenously was evaluated by using the preformed carrageenan granuloma pouch method. The anti-inflammatory activity of lipid emulsion dexamethasone was 5.6 times as potent as an equivalent amount of free dexamethasone. These results may indicate that corticosteroids which are incorporated in lipid emulsions are taken up by the reticuloendothelial system and some inflammatory cells much more than are free corticosteroids; thus they have a stronger anti-inflammatory activity. The clinical use of lipid emulsion corticosteroids for certain types of diseases is suggested.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-4967
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsion.
pubmed:publicationType
Journal Article, Comparative Study