Linked Life Data

6895682

Source:http://linkedlifedata.com/resource/pubmed/id/6895682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1982-3-22
pubmed:abstractText
1. The metabolic fate of [14C]fenclozic acid (ICI 54450) in rat was determined after intraduodenal administration at different doses. 2. Increasing the dose from 2 to 100 mg/kg resulted in a five-fold increase in drug-related material secreted in bile. 3. At a dose of 2 mg/kg the taurine conjugate was a relatively minor metabolite, whereas at 100 mg/kg this conjugate was the major metabolite in bile and urine. 4. Enhanced biliary secretion of the taurine conjugate in rats receiving multiple doses of fenclozic acid results in exposure of the intestinal cells to much greater concn. of drug-related metabolites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The enhanced biliary secretion of a taurine conjugate in the rat after intraduodenal administration of high doses of fenclozic acid.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't