Linked Life Data

6892555

Source:http://linkedlifedata.com/resource/pubmed/id/6892555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-3-24
pubmed:abstractText
Folic acid administered to rats in doses of 100, 200, 300, and 400 mg/kg of body weight resulted in alterations in renal tubular morphologic features and renal function, with the severity of the changes proportional to the dose. Renal cell incorporation of tritiated thymidine varied according to cell type and increased with the dose of folic acid. The results demonstrate (1) a spectrum of renal injury and subsequent repair; (2) a reduction in concentrating ability and creatinine clearance proportional to the dose of folic acid in the range of 100 to 300 mg/kg; and (3) increased mitotic activity at high doses of folic acid (300 and 400 mg/kg) of all renal tubular cell types examined, with collecting ducts demonstrating the greatest degree of regeneration. From these observations, we conclude that there is a predictable relationship between the dosage of folic acid and the abnormalities of morphologic features and function in this model of kidney injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0003-9985
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Folic acid-induced renal injury and repair. Correlation of structural and functional abnormalities.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.