Linked Life Data

6892518

Source:http://linkedlifedata.com/resource/pubmed/id/6892518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-2-26
pubmed:abstractText
The immunohistochemical and ultrastructural characteristics of involved lymph nodes from four patients with typical clinical and histopathologic features of malignant histiocytosis are reported. The neoplastic cells in all four cases had numerous irregular surface projections and pseudopodia, as well as lobulated or biolobed nuclei with macronucleoli. The cytoplasm contained many lysosomes, mitochondria, and polyribosomes, and displayed evidence of phagocytosis. Langerhans' granules were not identified. The ultrastructural features in the four cases were similar, effectively excluded an epithelial origin in each instance, and delineated morphological characteristics common to neoplastic macrophages. Intracytoplasmic muramidase (CM), an enzyme marker essentially restricted to cells of myeloid and true histiocytic origin, was identified with the unlabeled immunocytochemical technique and was strongly positive in neoplastic histiocytes at all stages of differentiation. Thus, fine structural features and the presence of CM are useful confirmatory studies in the diagnosis of malignant histiocytosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0003-9985
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Malignant histiocytosis. Ultrastructural and immunocytochemical characterization.
pubmed:publicationType
Journal Article